Ucellpharma

여러분의 건강한 삶을 위해 유셀파마는 연구합니다

     고콜레스테롤혈증

  • 콜레스테롤이 혈액 1dL당 240mg 이상
  • 동맥경화, 협심증, 심근경색 등과 같은 심혈관질환 발생의 증가
  • 유전적인요인, 식습관, 비만, 당뇨병, 갑상성질환, 특정약물 (경구피임약, 부신피질호르몬제)
    에 의해 유발됨

    유병률


  • 우리나라 30세 이상
  • 성인 중 21.5%가 이 질환을 갖고 있음
  • 2007년 부터 2017년까지 10년 사이에 2배 증가

      고콜레스테롤혈증


  • 콜레스테롤이 혈액 1 dL 당 240mg 이상
  • 동맥경화, 협심증, 심근경색 등과 같은 심혈관질환 발생의 증가
  • 유전적요인, 식습관, 비만, 당뇨병, 갑상성질환, 특정 약물(경구피임약, 부신피질호르몬제)에 의해 유발됨

    유병률 


  • 우리나라 30세 이상 
  • 성인 중 21.5%가 이 질환을 갖고 있음
  • 2007년 부터 2017년 까지 10년 사이에 2배 증가

약물의 작용기전

작용기전

효능(%change)

부작용

HMG CoA reductase inhibitors

↓ LDL (18-55), ↑ HDL (5-15), ↓ TG (7-30)

Myopathy, ↑Liver enzymes

Cholesterol absorption inhibitors

↓ LDL (14-18), ↑ HDL (1-3),

↓ TG (2)

Headache, GI distress

Nicotinic Acid

↓ LDL (15-30), ↑ HDL (15-35), ↓ TG (20-50)

Flushing, Hyperglycemia

Hyperuricemia, GI distress, Hepatotoxicity

Fibric Acids

↓ LDL (5-20), ↑ HDL (10-20),

↓ TG (20-50)

Dyspepsia, Gallstones, Myopathy

Bile Acid sequestrants

↓ LDL, ↑ HDL, No change in TG

GI distress, Constipation

↓absorption of other drugs



Statin의 한계

Statin side effect
CommonUncommonRare

•headache

•dizziness

•feeling sick

•feeling unusually tired or physically weak

•digestive system problems, such as constipation, diarrhea, indigestion or farting

•muscle pain

•sleep problems

•low blood platelet count

•being sick

memory problems

•hair loss

•pins and needles

•inflammation of the liver (hepatitis), which can cause flu-like symptoms

•inflammation of the pancreas (pancreatitis), which can cause stomach pain

•skin problems, such as acne or an itchy red rash

•sexual problems, such as loss of libido (reduced sex drive) or erectile dysfunction

•muscle weakness (myopathy)

•loss of sensation or tingling in the nerve endings of the hands and feet (peripheral neuropathy)

•tendon problems (tendons are tough cords of tissue that connect muscles to bones)


  • 고콜레스테롤혈증 시장의 90%를 차지하는 스타틴
    수많은 부작용으로 한계를 지니고 있음


  • 유셀파마는 이 한계를 극복할 실마리를 대마추출물에서 찾았음

약물의 작용기전

작용기전
효능 (% change)
부작용



HMG CoA reductase inhibitors

↓ LDL (18-55), ↑ HDL (5-15), ↓ TG (7-30)

Myopathy, ↑Liver enzymes

Cholesterol absorption inhibitors

↓ LDL (14-18), ↑ HDL (1-3), ↓ TG (2)

Headache, GI distress

Nicotinic Acid

↓ LDL (15-30), ↑ HDL (15-35)↓ TG (20-50)

Flushing, Hyperglycemia

Hyperuricemia, GI distress, Hepatotoxicity

Fibric Acids

↓ LDL (5-20), ↑ HDL (10-20), ↓ TG (20-50)

Dyspepsia, Gallstones, Myopathy

Bile Acid sequestrants

↓ LDL, ↑ HDL, No change in TG 

GI distress, Constipation

↓absorption of other drugs



Statin의 한계

Statin side effect
CommonUncommonRare
  • headache
  • dizziness
  • feeling sick
  • feeling unusually tired or physically weak
  • digestive system problems, such as constipation, diarrhea, indigestion or farting
  • muscle pain
  • sleep problems
  • low blood platelet count
  • being sick
  • memory problems
  • hair loss
  • pins and needles
  • inflammation of the liver (hepatitis), which can cause flu-like symptoms
  • inflammation of the pancreas (pancreatitis), which can cause stomach pain
  • skin problems, such as acne or an itchy red rash
  • sexual problems, such as loss of libido (reduced sex drive) or erectile dysfunction
  • muscle weakness (myopathy)
  • loss of sensation or tingling in the nerve endings of the hands and feet (peripheral neuropathy)
  • tendon problems (tendons are tough cords of tissue that connect muscles to bones)


  • 고콜레스테롤혈증 시장의 90%를 차지하는 스타틴 수많은 
    부작용으로 한계를 지니고 있음
  • 유셀파마는 이 한계를 극복할 실마리를 대마추출물에서 찾았음